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Return of Spontaneous Circulation (ROSC)

  • Return of spontaneous circulation (ROSC) is the return of a palpable pulse and substantial breathing effort after cardiac arrest.
  • Patients with ROSC may not regain consciousness
  • Signs of ROSC include
    • Breathing (or recognizable breathing effort, not occasional gasps)
    • Coughing
    • Movement (may not be purposeful)
    • Palpable pulse
    • Measureable blood pressure
    • Sudden increase (>10 mmHg) in end-tidal CO2 (EtCO2) on waveform capnography

Post Arrest Care

Ischemia may cause cardiac malfunction, which lasts for hours post resuscitation. Compromised tissue and organ function due to shock and respiratory failure may negatively impact oxygenation and perfusion.

Post resuscitation priorities include:

  • Maintaining adequate blood pressure and cardiac output
  • Restoration and maintenance of oxygenation and perfusion
  • Improving preload
  • Treating cardiac dysfunction, including arrhythmias
  • Maintaining Hgb levels within a normal range
  • Using energy-saving therapies such as mechanical ventilation and hypothermia as indicated

Evaluate and Identify

Monitor

  • Heart rate rhythm, BP, and pulse pressure
  • Urinary output
  • In ICU settings, measure BP via arterial line (A line), central venous pressure (CVP), central O2 levels, and cardiac output using advanced technologies

Physical Assessment

  • Perform frequently
  • Pay attention for signs of good/poor perfusion
  • Monitor end-organ function to evaluate perfusion

Tests

  • Arterial blood gas (ABG)
  • Hemoglobin and hematocrit
  • Glucose, CBC, electrolytes, liver and renal panels, calcium lactate
  • Oxygen saturation (O2 sat)
  • Troponin levels
  • Chest X-ray (CXR)
  • 12-lead ECG
  • Echocardiogram

Intervene

  • Intravascular Volume
    • Obtain secure venous access; using at least 2 sites if possible.
    • Administer fluid boluses of 10-20 mL/kg isotonic solution over 5-20 minutes to restore intravascular volume. If heart failure is present, administer fluid boluses of 5-10 mL/kg isotonic solution over 10-20 minutes as needed.
    • Consider administration of colloids or blood products if indicated.
  • Blood Pressure
    • Treat hypotension aggressively.
    • Use fluids or vasoactive medications.
    • If hypertension occurs, evaluate cause. Causes may include medication, pain, seizures, or anxiety.
  • Arrhythmias
    • Control with medication and/or electrical therapy
    • Consult pediatric cardiologist
  • Oxygenation and Perfusion
    • High concentration oxygen
    • Titrate SpO2 to 94%-99%
    • Consider administration of RBCs
    • Consider positive pressure ventilation
  • Metabolic Needs
    • Intubate and provide mechanical ventilation if indicated
    • Control pain, agitation, and anxiety
    • Use antipyretics if fever is present
  • Myocardial Dysfunction
    • Expect dysfunction for 24 hours post arrest
    • Manage with medications
    • Correct underlying problems that add stress to the cardiovascular system

Targeted Temperature Management

Controlled trials have failed to show a benefit of targeted temperature management in comatose children after resuscitation from arrest in the hospital. Thus, routine use of targeted temperature management is not recommended. On the other hand, fever should be avoided or aggressively treated in comatose children after resuscitation.

It is reasonable for children who had arrest outside of the hospital to be treated with 5 days of normothermia (36°C to 37.5°C) or 2 days of continuous hypothermia (32°C to 34°C) followed by 3 days of normothermia.

Post Resuscitation Management of Shock

  • Shock may occur post resuscitation due to blood loss, impaired contractility of the heart, changes in vascular resistance, or increased pulmonary vascular resistance
  • Perfusion may be improved by enhanced by
    • Increasing preload with fluid boluses
    • Improving contractility via the use of inotropes or inodilators. Treating poisonings, drug toxicities, hypoxia, and electrolyte imbalances improves contractility. Measures which correct acid–base imbalances, hypoglycemia, and hypocalcemia—enhance contractility
    • Improving afterload with vasopressors or vasodilators
    • Controlling heart rate. Epinephrine and antiarrhythmics may be useful indicated. Pacing and correction of hypoxia helps to normalize the heart rate
  • Hypotensive shock
    • Epinephrine IV/IO 0.1-1mcg/kg/minute
    • Dopamine IV/IO 10-20 mcg/kg/min (initial infusion rate)
    • Norepinephrine IV/IO1-2 mcg/kg/min
  • Normotensive shock
    • Inamrinone IV/IO,administer a loading dose of 0.75-1 mg/kg over 5 minutes. May repeat x2. Follow with a drip of 5-10 mcg/kg/min.
    • Dobutamine, dopamine, low dose epinephrine, and milrinone may be used

Fluids

  • Initial fluids include lactated Ringer’s and normal saline, isotonic crystalloids
  • Dextrose should be included in maintenance to prevent hypoglycemia
  • Potassium is generally recommended, supplement in deficiency
  • To meet general maintenance requirements, administer:
    • Infants weighing <10 kg: 4mL/kg/hr
    • Children weighing between 10 and 20kg: 40mL/kg/hr+2mL/kg
    • Children over 20 kg: 60mL/kg/hr+1mL/kg/hr for each kg over 20

Post-Resuscitation: Respiratory System

Evaluate, Identify,Intervene

  • Assess airway, oxygenation, and ventilation.
  • Intubation may be needed. If not, use partial or full-face mask for O2 delivery.
  • If manual ventilation is in use, consider mechanical ventilation.
  • Maintain O2 sat > 94% to reduce reperfusion injury and cardiac arrest.
  • Maintain ventilation. Desired PaCO2 levels depend upon the child’s diagnosis. Normal levels are 35-45 mmHg. Do not routinely hyperventilate.
  • Use clinical assessment, ECG monitoring, O2 sat readings, ABGs, and capnotherapy to monitor oxygenation.
  • Confirm proper ET tube placement whenever the child is moved.
  • Tape ET tube carefully.
  • Monitor for signs of respiratory distress.
  • Use Chest X-ray to confirm tube placement and assess cardiopulmonary status.
  • If SpO2<90% while receiving 100% O2, consider ventilation support or ET tube placement and PEEP.
  • Children with cardiac lesions may require higher levels of O2.
  • Use analgesics such as fentanyl or morphine.
  • Administer sedatives to all responsive intubated children.
  • Smaller doses of sedatives and analgesics may be indicated for children who are hemodynamically unstable
  • Employ neuromuscular blocking agents for children who have signs of poor ventilation and perfusion despite analgesia and sedation.

Post-Resuscitation: Renal System

Goals

  • Prevent secondary damage to the kidneys
  • Maintain fluid and electrolyte balance and kidney function
  • Optimize renal perfusion
  • Correct acid-base imbalances

Evaluate and Identify

  • Insert an indwelling catheter for accurate measurement of output
  • Monitor urine output. Adequate output= >1 mL/kg/hr in infants and children. Normal output for adolescents is >30 mL/hr.
  • Excessive output may indicate metabolic conditions or may occur secondary to diuretic use
  • Perform an examination of the abdomen, assessing for a distended bladder
  • Monitor for oliguria,which may be the result of renal disease, obstruction, hypovolemia, or impaired circulation
  • Labs include: BUN/creatinine, electrolytes, urinalysis, acid-base assessment, glucose, anion gap, and lactate concentration levels

Intervene

  • Administer fluids and vasoactive medications to enhance renal perfusion and restore acid-base balance
  • If fluid overload is suspected, employ diuretics such as furosemide (Lasix)
  • Avoid medications that are detoxified via the kidneys if urinary function is impaired
  • Restrict fluids in oliguric children if intravascular volume is adequate in case renal failure is present
  • Consider the use of sodium bicarbonate

PostResuscitation: Gastrointestinal System

Goals

  • Restore and maintain GI, hepatic, and pancreatic function
  • Minimize aspiration
  • Support perfusion
  • Prevent and relieve distention
  • Correct electrolyte imbalances that may contribute to ileus formation

Evaluate and Identify

  • Monitor gastric drainage
  • Perform an assessment of the abdomen
  • Labs include: LFTs, amylase, lipase levels, and studies to evaluate acid-base balance
  • Assess for signs of bowel ischemia
  • Imaging studies may include CT scan of the abdomen and ultrasounds of the pelvic and abdominal organs

Intervene

  • For gastric distention, insert an OG or NG tube. A sump tube is superior to a single lumen feeding tube
  • To prevent and treat ileus formation, insert OG or NG tube and connect to continuous suction; monitor and maintain a healthy balance of electrolytes
  • If liver failure occurs, infuse glucose; if bleeding occurs, administer blood products as needed

PostResuscitation: Hematological System

Goals

  • Optimization of the oxygen carrying capacity of blood
  • Restore and/or maintain coagulation function

Evaluate and Identify

  • Conduct a physical assessment to monitor for signs of internal or external bleeding
  • Evaluate skin and mucous membranes for pallor, petechiae, or bruising
  • Laboratory studies include CBC, Hgb, Hct, PT, PTT, D-dimer, INR

Intervene

  • If hemorrhagic shock occurs, administer isotonic crystalloid and PRBCs
  • Use platelets to correct thrombocytopenia
  • Seek expert assistance for massive hemorrhages
  • Administer FFP if the child is bleeding, at risk for bleeding,or has abnormal clotting study results
  • If the PT is elevated, administer Vitamin K

Transport of the Critically Ill Child

Planning and Communication

  • Assessment, monitoring, treatment, stabilization, communication, and documentation skills are needed before, during, and after transport. These aspects are important whether a patient is being transported between facilities or between units.
  • A transport plan requires coordination between personnel from the sending and receiving facilities as well as with the transport team.
  • Excellent communication with the child’s family is critical

Regulationsand Preparation

  • The federal Emergency Medical Treatment and Active Labor Act, (EMTALA) regulates transport between facilities.
  • Advance preparation for transport of patients includes identification of tertiary care facilities and transport agencies, maintain supplies, and transport protocols.
  • If an infectious illness is suspected, cultures must be obtained and antibiotics administered. Personnel from the sending facility must notify the transport team and receiving facility workers to ensure that proper precautions are made. Use universal precautions for all patients. Employ additional precautions if a communicable disease is suspected.
  • Obtain written consent from the child’s parents/guardians prior to transport.
  • Consider advanced airway placement prior to transport if the child does not have one. Confirm placement.
  • Stabilize the child.
  • Ensure that all equipment is securely attached.
  • Provide analgesia and sedation prior to transport if indicated.
  • Copy medical records.
  • Prepare medication, blood products, and infusions needed for transport.
  • Optimization of the oxygen carrying capacity of blood.
  • Restore and/or maintain coagulation function.
  • The referring physician is responsible for notifying the receiving facility if a child’s condition changes after the initial report to the receiving facility was conducted.

Reports, documentation, transport

  • Date, time, vital statistics, medical history, current problem, medications, fluids, equipment in use, presence of infectious disease, family contact information, labs and imaging results, assessment, information about care provided to stabilize child, reason for transfer, name of receiving physician and facility.
  • Document names of people who report was provided to and any other pertinent information.
  • Follow facility guidelines and federal regulations regarding providing and obtaining follow-up information.
  • The majority of transports occur via ground ambulance. Helicopters are used for longer distance transports. Children who have a surgical emergency may benefit from helicopter transport. Fixed wing airplanes are used to transport children from remote locations and for long distance trips.

Pediatric Critical Care Transport Team

  • Volunteer or professional EMS personnel, pediatric transport experts, personnel from the referring facility, and critical care transport experts.
  • Engage a pediatric transport team if the child:
    • Requires intensive care services from the receiving facility
    • Has a significant risk of cardiopulmonary or neurologic deterioration during transport
    • Is stable, but has just survived a life-threatening event, such as cardiac arrest, SIDS, status epilepticus, or severe shock
    • Has experienced a life-threatening event that has a high probability of recurrence
  • It is often preferable to wait for the arrival of a specialized pediatric transport team even if it delays transport.
  • If a child needs an immediate surgical intervention, do not wait for a specialized team.
  • Broad criteria are used to determine whether a special pediatric transport team is utilized.

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